Browsing by Author "Burgess, Kevin"
Now showing items 1-20 of 64
-
Cui, Xiuhua (Texas A&M University, 2005-08-29)A library of iridium complexes featuring oxazoline and imidazol-2-ylidene ligands were synthesized by reaction of a library of imidazoles with a second library of oxazoline iodides. These complexes were active catalysts ...
-
Zhu, Ye (2012-07-16)Hydrogenation of "largely unfunctionalized" alkenes has been an active area of research for about a decade. Many catalysts have been prepared but we noticed that comparatively few substrates have been studied and none of ...
-
Tang, Yu (2020-06-04)Very little is known about how tissues can regulate their size. In one possible mechanism, cells in a tissue secrete a factor that inhibits their proliferation, and as the tissue gets bigger, the concentration of the factor ...
-
Nnanabu, Ernest (2009-06-02)Over the years, the Burgess group has been focusing on the preparation and testing of small molecules that mimic protein secondary structures for protein-protein interactions. The most successful compounds made are C10 ...
-
Picot, Alexandre (Texas A&M University, 2005-02-17)The degradation of phosphate triesters is efficiently catalyzed by organophosphate hydrolases (OPH). While a number of recent studies have focused on optimizing the rate of hydrolysis observed with the native enzyme, no ...
-
Sanchez, Richard P., Jr (2010-01-14)Stereoselective carbon?carbon bond formation is one of the most important types of bond construction in organic chemistry. A mild and acid free catalyst system for the hydrovinylation reaction utilizing a cationic, ruthenium ...
-
Wang, Zhipeng (2018-04-30)In the recent decade, an increasing amount of protein post-translational modifications (PTMs) have been discovered, which are important epigenetic markers widespread on nucleic and cytoplasmic proteins. Lysine (Lys), as ...
-
Kang, Jun (2011-10-21)The homoaldol reaction is one of the most powerful methods for the construction of C–C bonds as well as 1,4-oxygenated compounds yet this reaction remains in challenging tasks due to the instability of homoenolates which ...
-
Brahimi, Fouad; Ko, Eunhwa; Malakhov, Andrey; Burgess, Kevin; Saragovi, H. Uri; Costa-Neto, Claudio M. (PloS One, 2014)
-
Park, Chihyo (Texas A&M University, 2007-04-25)The solid phase combinatorial method is an excellent tool for the modulation of protein-protein interactions through focused library generations. Nucleophilic aromatic substitution reactions with an iodinated template on ...
-
Lam, Sang Q. (Texas A&M University, 2007-04-25)In an effort to partially mimic the complex interaction between nerve growth factor (NGF) and its membrane-bound tyrosine kinase A receptor (TrkA), several small organic molecules with functionalities similar to the ...
-
Lin, Yun (2012-07-16)Nanomedicine, the medical application of nanotechnology, uses nanoscale objects that exist at the interface between small molecule and the macroscopic world for medical diagnosis and treatment. One of the healthcare ...
-
Thivierge, Cliferson (2012-07-16)The challenges in modern biological imaging applications are two-fold: (i) to develop better methods of imaging, and (ii) develop dyes that are suitable for these methods. This dissertation deals with the design and ...
-
Xin, Dongyue (2016-02-22)Protein-protein interactions (PPIs) play key regulatory roles in biological systems, and some of these are interesting drug targets. Consequently, it is important to develop generally applicable methods to identify small ...
-
Taechalertpaisarn, Jaru (2018-02-01)Protein-protein interactions (PPIs) are one of the basic mechanisms in cellular biology, but also involve in diseases if they are dysregulation. Disrupting aberrant PPI activities is useful in medicinal chemistry. One ...
-
Wu, Liangxing (2010-10-12)New methodologies for the efficient syntheses of 4,4-difluoro-4-bora-3a,4adiaza- s-indacenes (BODIPYs) and rosamines were developed. A serendipitous discovery led to a new reaction which afforded BODIPYs in high yields. ...
-
Han, Junyan (2012-02-14)A xanthene-BODIPY cassette is used as a ratiometric intracellular pH reporter for imaging protein-dye conjugates in living cells. A model was hypothesized to explain the pH-dependent energy transfer efficiencies from the ...
-
Usama, Syed Muhammad (2019-06-05)Optical imaging is most favorable for dyes that absorb in the near-IR region because tissue is more permeable to light >750 nm. A particular set of cyanine dyes localize and persists in almost all solid tumors (e.g. ...
-
Hampton, Joshua Trae (2023-05-03)Peptides represent an emerging class for drug discovery, with the number of therapeutic peptides nearly doubling in the past twenty years. In spite of the development of many different screening techniques to identify ...
-
Jiang, Zhengyang (2019-05-21)Cancer has become one of the biggest threats to human health. In most cases, cancer cells can be differentiated from normal tissues via the overexpression of certain cellular membrane proteins. Improved therapeutic effects ...